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5 marksStructure and Roles of Nucleic Acids

CAPE Biology Unit 1 · 2012 · Paper 2 · Question 5(a)(ii)

Using sickle-cell anaemia as the example, explain the sequence of changes triggered by the gene mutation that leads to the cells becoming sickle shaped.

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  1. 5(a)(i)Distinguish between the terms ‘gene mutation' and ‘chromosome mutation'.[4 marks]
  2. 5(b)(i)Outline the procedure of somatic gene therapy, giving FOUR key steps.[4 marks]
  3. 5(b)(ii)With reference to cystic fibrosis, comment on ONE difficulty in using gene therapy to treat diseases.[2 marks]

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